Cyclic ureas as ortho directing substituents

JP Meigh, M Álvarez, JA Joule

Index: Meigh; Alvarez; Joule Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 17 p. 2012 - 2021

Full Text: HTML

Citation Number: 26

Abstract

An alternative retrosynthetic analysis to that used for previous work 2,3,4 is shown in Scheme 1: here we propose that the pyrrole ring would be formed at a late stage from a structure such as 1 and that this would be developed from a pyridine 2 in which the two pyrimidine substituents would be introduced sequentially. A successful implementation of this route would enable the development of a library of variolin analogues, including, by alternating the order of ...