Preparation of α-methylene ketones by direct methylene transfer

…, EP Siqueira-Filho, M Mancilha, PJS Moran

Index: Rodrigues, J. Augusto R.; Siqueira-Filho, Ezequias P.; De Mancilha, Moacir; Moran, Paulo J. S. Synthetic Communications, 2003 , vol. 33, # 2 p. 331 - 340

Full Text: HTML

Citation Number: 12

Abstract

View all references The advantages of the direct methylene transfer for the formation of α-methylene ketones are the availability of the starting materials and the fact that this is a one pot reaction. The reactions are not regiospecific and highly sensitive to the more acidic α hydrogen of the carbonyl group. The reaction has been applied to cyclic and acyclic ketones and extended to the synthesis of vinyl ketones, α-methylene aldehydes, esters and lactones.