General and facile synthesis of indoles with oxygen-bearing substituents at the benzene moiety

Y Kondo, S Kojima, T Sakamoto

Index: Kondo, Yoshinori; Kojima, Satoshi; Sakamoto, Takao Journal of Organic Chemistry, 1997 , vol. 62, # 19 p. 6507 - 6511

Full Text: HTML

Citation Number: 129

Abstract

Indoles with oxygen-bearing substituents such as a methoxy or (triisopropylsilyl) oxy group at all of the positions of the benzene moiety were synthesized by cyclization of tert-butyl methoxy (or (triisopropylsilyl) oxy)-2-((trimethylsilyl) ethynyl) phenyl) carbamates with potassium tert-butoxide in tert-butyl alcohol. The (ethynylphenyl) carbamates were synthesized by the palladium-catalyzed reaction of (trimethylsilyl) acetylene and the ...