Synthesis of eight stereoisomers of pochonicine: nanomolar inhibition of β-N-acetylhexosaminidases

JS Zhu, S Nakagawa, W Chen, I Adachi…

Index: Hernandez, J. Nicolas; Crisostomo, Fernando R. Pinacho; Martin, Tomas; Martin, Victor S. European Journal of Organic Chemistry, 2007 , # 30 p. 5050 - 5058

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Citation Number: 26

Abstract

... J. Org. ... Finally, the second pyrrolidine ring could be assembled through dihydroxylation of the allyl group followed by intramolecular S N 2 ... After oxidation of the unmasked primary hydroxyl group in 13L with Dess–Martin periodinane (DMP), the resulting aldehyde 14L was ...

~85%

~65%

Synthesis and evaluation of acyl protein thioesterase 1 (APT...

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Synthesis of homoceramides, novel ceramide analogues, and th...

[De Jonghe, Steven; Lamote, Inge; Venkataraman, Krishnan; Boldin, Swetlana A.; Hillaert, Ulrik; Rozenski, Jef; Hendrix, Chris; Busson, Roger; De Keukeleire, Denis; Van Calenbergh, Serge; Futerman, Anthony H.; Herdewijn, Piet Journal of Organic Chemistry, 2002 , vol. 67, # 3 p. 988 - 996]

Synthesis of a trisubstituted 1, 4-diazepin-3-one-based dipe...

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A convenient synthesis of l-α-vinylglycine from l-homoserine...

[Berkowitz, David B.; Smith, Marianne K. Synthesis, 1996 , # 1 p. 39 - 41]

Use of L-aspartic acid β-semialdehyde in the synthesis of mo...

[Baldwin, J. E.; Flinn, A. Tetrahedron Letters, 1987 , vol. 28, # 31 p. 3605 - 3608]