Tetrahedron

Reaction of Grignard reagents with carbonyl compounds under continuous flow conditions

E Riva, S Gagliardi, M Martinelli, D Passarella, D Vigo…

Index: Riva; Gagliardi; Martinelli; Passarella; Vigo; Rencurosi Tetrahedron, 2010 , vol. 66, # 17 p. 3242 - 3247

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Citation Number: 50

Abstract

This contribution details how a continuous flow reactor was used to react carbonyl compounds with Grignard reagents at room temperature in an efficient and safe manner. Flow rate, residence time and temperature were optimized for the preparation of a small collection of secondary and tertiary alcohols. Excellent yields and general applicability were observed using the set-up protocol. The procedure was also applied for the preparation of ...