Chemical and enzymatic syntheses of 6-deoxyhexoses. Conversion to 2, 5-dimethyl-4-hydroxy-2, 3-dihydrofuran-3-one (Furaneol) and analogs

…, FP Mazenod, GM Whitesides

Index: Wong, Chi-Huey; Mazenod, Francois P.; Whitesides, George M. Journal of Organic Chemistry, 1983 , vol. 48, # 20 p. 3493 - 3497

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Citation Number: 82

Abstract

This paper describes procedures using enzyme-catalyzed and conventional chemical steps for the preparation of unusual sugars. We have described previously the use of aldol condensations catalyzed by aldolase (EC 4.1. 2.13, from rabbit muscle) as a route to isotopically labeled glucose 6-phosphate and fructose 6-phosphak3 The work reported here uses aldolase in analogous preparations of 6-deoxyhexoses and 6, 7-dideoxyheptoses ...