Synthesis and anticonvulsant activity of 1-substituted-7-benzyloxy-4, 5-dihydro-[1, 2, 4] triazolo [4, 3-a] quinoline

…, ZF Xie, HR Piao, G Li, KY Chai, ZS Quan

Index: Cui, Li-Jing; Xie, Zhi-Feng; Piao, Hu-Ri; Li, Gao; Chai, Kyu-Yun; Quan, Zhe-Shan Biological and Pharmaceutical Bulletin, 2005 , vol. 28, # 7 p. 1216 - 1220

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Citation Number: 38

Abstract

Starting from 6-hydroxy-3, 4-dihydro-1H-quinoline-2-one, a series of 1-substituted-7- benzyloxy-4, 5-dihydro-[1, 2, 4] triazolo [4, 3-a] quinolines was synthesized and their structures were characterized using IR, 1 H-NMR, MS, and elemental analysis techniques. Anticonvulsant activity was evaluated in the maximal electroshock (MES) test, subcutaneous pentylenetetrazol (scMet) test, and rotarod neurotoxicity test. The most active compound ...