Chemische Berichte

Cyclopropan??Derivate, 3.(1??Alkylcyclopropyl) ketone durch Acylierung von α??substituierten γ??Lactonen

G Böhrer, P Böhrer, R Knorr

Index: Boehrer, Gerald; Boehrer, Petra; Knorr, Rudolf Chemische Berichte, 1990 , vol. 123, # 11 p. 2167 - 2172

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Citation Number: 6

Abstract

The 2-acylation of 2-substituted 4-butanolides 2 is moderately sensitive to steric crowding, whereas the subsequent ringopening of 2-acyl-2-alkyl-4-butanolides 4, 11 to give y-chloro ketones 6, 12 by chloride-transferring acid derivatives becomes difficult with bigger lactone substituents. Similar observations pertain to the preparation of y-chlorobutanoyl chlorides 10 from 2-alkyl-4-butanolides 2. The proper choice of the starting 4-butanolides (2a, b or 14 ...