The reactivity of DPPA is based on the oxophilic nature of the phosphorous center facilitating the immediate substitution of a hydroxy moiety, whereas nonactivated alcohols are transformed only under more drastic conditions. [6] The ring-opening reaction of the epoxides with the phosphoryl azide can be realized in the presence of lithium salts. [7] In the resulting azidohydrins the alkoxy moiety is attached to the diphenylphosphoryl system representing a good leaving group. ...
