Chemical communications

Hydrophobic amplification of noncovalent organocatalysis

CM Kleiner, PR Schreiner

Index: Kleiner, Christian M.; Schreiner, Peter R. Chemical Communications, 2006 , # 41 p. 4315 - 4317

Full Text: HTML

Citation Number: 71

Abstract

Catalysis in water depends on the ability of the catalysts to tolerate water on the one hand and to remain active on the other; water-soluble Lewis acids underline this possibility. 6 Organocatalytic reactions have thus far mostly been carried out in organic solvents although some of the key ideas behind organocatalysts derive from enzyme active site motifs that display their activity in their natural aqueous environments. Noncovalent organocatalysis 7 that largely builds on ...