Australian Journal of Chemistry

Synthesis of Casein-Related Peptides and Phosphopeptides. VII. The Efficient Synthesis of Ser (P)-Containing Peptides by the Use of Boc-Ser (PO3R2)-OH …

JW Perich, PF Alewood, RB Johns

Index: Perich, John W.; Alewood, Paul F.; Johns, R. B. Australian Journal of Chemistry, 1991 , vol. 44, # 2 p. 233 - 252

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Citation Number: 45

Abstract

Abstract A new approach to the synthesis of Ser (PO 3 R 2)-containing peptides by using five protected Boc-Ser (PO 3 R 2)-OH (R= phenyl, ethyl, methyl, benzyl, t-butyl) derivatives is described. The five Boc-protected derivatives are prepared by a simple three-step synthetic procedure which features the use of either (A) diphenyl or dialkyl phosphorochloridate/ pyridine, or (B) dialkyl N, N-diethylphosphoramidite/1H-tetrazole-m-chloroperoxybenzoic ...