A highly active catalytic system for Suzuki–Miyaura cross-coupling reactions of aryl and heteroaryl chlorides in water

…, C Zhao, ZJ Han, J Yuan, X Zhu, Q Yang…

Index: Mao, Shu-Lan; Sun, Yue; Yu, Guang-Ao; Zhao, Cui; Han, Zhi-Jun; Yuan, Jia; Zhu, Xiaolei; Yang, Qihua; Liu, Sheng-Hua Organic and Biomolecular Chemistry, 2012 , vol. 10, # 47 p. 9410 - 9417

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Citation Number: 45

Abstract

An easily available Pd (OAc) 2/(2-mesitylindenyl) dicyclohexylphosphine/Me (octyl) 3N+ Cl−/K3PO4· 3H2O catalytic system was developed and it shows high catalytic activity in the Suzuki–Miyaura cross-coupling reaction of a diverse array of aryl and heteroaryl chlorides in water. Notably, this catalytic system also works with ultra-low loading of the catalyst with high turnover numbers.