Chemosphere

Synthesis of polychlorinated biphenyls and their metabolites with a modified Suzuki-coupling

I Kania-Korwel, S Parkin, LW Robertson, HJ Lehmler

Index: Kania-Korwel, Izabela; Parkin, Sean; Robertson, Larry W.; Lehmler, Hans-Joachim Chemosphere, 2004 , vol. 56, # 8 p. 735 - 744

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Citation Number: 23

Abstract

A modified procedure for the synthesis of polychlorinated biphenyls (PCBs) utilizing the Suzuki-coupling, a palladium-catalyzed cross-coupling reaction, is described. The coupling of (chlorinated) benzene boronic acids with bromochlorobenzenes, using Pd (dppf) 2Cl2 (dppf= 1, 1′-bis (diphenylphosphino) ferrocene) as the catalyst and aqueous sodium carbonate as the base, gave the desired PCB congeners in moderate to good yields. ...