The cyclization of ethyl cyanoacetate and salicylaldehyde or 3-methoxysalicylaldehyde with ketones by means of ammonium acetate

A Sakurai, H Midorikawa, Y Hashimoto

Index: Sakurai,A.; Midorikawa,H. Bulletin of the Chemical Society of Japan, 1970 , vol. 43, p. 2925 - 2933

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Citation Number: 14

Abstract

Various substituted benz [f] isoquinolines were readily prepared by the condensation of ethyl cyanoacetate and salicylaldehyde or 3-methoxysalicylaldehyde with aliphatic ketones (acetone, diethyl ketone, methyl pentyl ketone, methyl isopentyl ketone, etc.) or aromatic ketones (acetophenone, o-hydroxyacetophenone, m-nitroacetophenone, propiophenone, etc.) in the presence of ammonium acetate. On the other hand, condensation with cyclic ...