A nucleotide dimer synthesis without protecting groups using montmorillonite as catalyst

…, MF Aldersley, DV Zagorevskii, JP Ferris

Index: Joshi, Prakash C.; Aldersley, Michael F.; Zagorevskii, Dmitri V.; Ferris, James P. Nucleosides, Nucleotides and Nucleic Acids, 2012 , vol. 31, # 7 p. 536 - 566

Full Text: HTML

Citation Number: 8

Abstract

A synthesis has been developed providing nucleotide dimers comprising natural or unnatural nucleoside residues. A ribonucleoside 5′-phosphorimidazolide is added to a nucleoside adsorbed on montmorillonite at neutral pH with the absence of protecting groups. Approximately 30% of the imidazolide is converted into each 2′-5′ dimer and 3′- 5′ dimer with the rest hydrolyzed to the 5′-monophosphate. Experiments with many ...