1-[3-(Diarylamino) propyl] piperidines and related compounds, potential antipsychotic agents with low cataleptogenic profiles

…, IC Pattison, DE Butler, HA DeWald…

Index: Wise, Lawrence D.; Pattison, Ian C.; Butler, Donald E.; DeWald, Horace A.; Lewis, Edward P.; et al. Journal of Medicinal Chemistry, 1985 , vol. 28, # 5 p. 606 - 612

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Citation Number: 6

Abstract

On the basis of a structural model of the postsynaptic dopaminergic antagonist pharmacophore, a series of 1-[3-(diarylamino) propyl] piperidines and related compounds was synthesized and evaluated for potential antipsychotic activity. For a rapid measure of activity, the target compounds were initially screened in vitro for inhibition of [3H] haloperidol binding and in vivo in a test of locomotor activity. Behavioral efficacy of compounds ...