The Journal of organic chemistry

Total synthesis of ellipticine quinones, olivacine, and calothrixin B

N Ramkumar, R Nagarajan

Index: Ramkumar, Nagarajan; Nagarajan, Rajagopal Journal of Organic Chemistry, 2014 , vol. 79, # 2 p. 736 - 741

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Citation Number: 25

Abstract

A direct route to the synthesis of biologically active ellipticine quinones, olivacine, and calothrixin B is described. The prominent key steps involved are Friedel–Crafts hydroxyalkylation followed by oxidation and directed ortho-lithiation reactions of readily available indole-2-carboxylate esters with appropriately substituted pyridine and quinoline carboxaldehydes.

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