Tetrahedron letters

Intramolecular arylation of benzimidazoles via Pd (II)/Cu (I) catalyzed cross-dehydrogenative coupling

KC Pereira, AL Porter, B DeBoef

Index: Pereira, Kyle C.; Porter, Ashley L.; Deboef, Brenton Tetrahedron Letters, 2014 , vol. 55, # 10 p. 1729 - 1732

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Citation Number: 6

Abstract

Abstract Electron poor benzimidazole substrates were arylated via an intramolecular cross- dehydrogenative coupling (CDC) reaction. These CDC reactions were catalyzed by a Pd (II)/Cu (I) catalyst system, capable of producing moderate yields on a large library of substrates. The substrate scope consisted of tethered arene-benzimidazoles that upon coupling, produced a fused polycyclic motif.