Efficient,“tin-free” radical cyclization to aromatic systems. Synthesis of 5, 6, 8, 9, 10, 11-hexahydroindolo [2, 1-a] isoquinolines

…, R Cruz-Almanza, JM Muchowski…

Index: Menes-Arzate, Martha; Martinez, Roberto; Cruz-Almanza, Raymundo; Muchowski, Joseph M.; Osornio, Yazmin M.; Miranda, Luis D. Journal of Organic Chemistry, 2004 , vol. 69, # 11 p. 4001 - 4004

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Citation Number: 44

Abstract

Efficient radical cyclization of alkyl iodides to various aromatic systems including pyrrole, indole, isoquinolone, pyridone, and benzene, mediated by dicumyl peroxide, is described. The methodology was used to provide access to 5, 6, 8, 9, 10, 11-hexahydroindolo [2, 1-a] isoquinoline derivatives.