α-Nitro ketone synthesis using N-acylbenzotriazoles

…, AAA Abdel-Fattah, AV Gromova, R Witek…

Index: Katritzky, Alan R.; Abdel-Fattah, Ashraf A. A.; Gromova, Anna V.; Witek, Rachel; Steel, Peter J. Journal of Organic Chemistry, 2005 , vol. 70, # 23 p. 9211 - 9214

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Citation Number: 29

Abstract

Readily available N-acylbenzotriazoles 2a-l (derived from a variety of aliphatic,(hetero) aromatic, and N-protected α-amino carboxylic acids) smoothly convert primary 3a-c and α- functionalized primary nitroalkanes 3d into the corresponding α-nitro ketones 5a-p in yields of 39-86%(average 63%).