Bioorganic & medicinal chemistry letters

Synthesis and photophysical properties of new fluorinated benzo [c] xanthene dyes as intracellular pH indicators

J Liu, Z Diwu, WY Leung

Index: Liu, Jixiang; Diwu, Zhenjun; Leung, Wai-Yee Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 22 p. 2903 - 2905

Full Text: HTML

Citation Number: 92

Abstract

Two new fluorinated benzo [c] xanthene dyes were synthesized by reaction of fluorinated 1, 6-dihydroxynaphthalenes with 2, 4-(and 2, 5)-dicarboxy-3′-dimethylamino-2′- hydroxybenzophenone. The two critical fluorinated 1, 6-dihydroxynaphthalene intermediates were prepared via a regioselective route. The fluorinated benzo [c] xanthene dyes exhibit desired lower pKa values (6.4 and 7.2, respectively) than their parent compound (pKa= ...