α-FUNCTIONAL CYCLOALKYLPHOSPHONATES I. SYNTHESIS

…, E About-jaudet, N Collignon

Index: Nasser, Jamal; About-Jaudet, Elie; Collignon, Noel Phosphorus, Sulfur and Silicon and the Related Elements, 1990 , vol. 54, # 1/4 p. 171 - 179

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Abstract

Abstract Cycloalkylphosphonates 2 of different sizes (from cyclopropyl to cycloheptyl) bearing various functional groups Z in a position were synthesized by bis-alkylation of α- functional methylphosphonates 1 and Ω-dibromoalkanes in presence of base. The choice of the basic system is determined by the nature of Z. With powerful electron-withdrawing groups, NaH-THF/DMSO (Method A, for Z= CN, SO2R) or liquid-solid phase transfer ...