Journal of Fluorine chemistry

Synthesis of novel 1, 4, 5-trisubstituted 3-trifluoromethylpyrazoles via microwave-assisted Stille coupling reactions

SL Jeon, JH Choi, BT Kim, IH Jeong

Index: Jeon, Sung Lan; Choi, Ji Hoon; Kim, Bum Tae; Jeong, In Howa Journal of Fluorine Chemistry, 2007 , vol. 128, # 10 p. 1191 - 1197

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Citation Number: 24

Abstract

1, 5-Disubstituted 3-trifluoromethylpyrazoles were reacted with N-bromosuccinimide in DMF at room temperature or 70–80° C for 1–2h to afford the corresponding 4-bromo-substituted pyrazoles 2 in 95–99% yields. The microwave-assisted Stille coupling reactions of 2 with arylstannanes having a substituent on the benzene ring and allylstannane in refluxing CH3CN in the presence of Pd (PPh3) 4 provided the corresponding 1, 4, 5-trisubstituted 3- ...