Enzymatic synthesis of enantiomerically enriched D-and L-3-silylated alanines by deracemization of DL-5-silylmethylated hydantoins

RJ Smith, M Pietzsch, T Waniek, C Syldatk…

Index: Smith, Richard J.; Pietzsch, Markus; Waniek, Thomas; Syldatk, Christoph; Bienz, Stefan Tetrahedron Asymmetry, 2001 , vol. 12, # 1 p. 157 - 165

Full Text: HTML

Citation Number: 31

Abstract

The hydantoinase process was shown to be extendable to the production of highly lipophilic, silicon-containing amino acids. Two hydantoinases of different origin and stereoselectivities and one lN-carbamoylase were used for the highly stereoselective bioconversion of (dimethyl) phenylsilyl-and 1-methyl-1-silacyclopentyl substituted alanine derivatives. The enantiomeric purities and absolute configuration of the products were determined with ...