Synthesis

Efficient synthesis of iminoctadine, a potent antifungal agent and polyamine oxidase inhibitor (PAO)

F Raffi, F Corelli, M Botta

Index: Raffi, Francesco; Corelli, Federico; Botta, Maurizio Synthesis, 2007 , # 19 p. 3013 - 3016

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Citation Number: 7

Abstract

Abstract Iminoctadine (1, 17-diguanidino-9-azaheptadecane), isolated from a mixture of polyamines and guanidines known as guazatine that is used in agriculture as a fungicide, showed interesting activity as human antifungal agent and PAO inhibitor. In this paper, we propose a straightforward synthetic strategy for obtaining pure iminoctadine tris (trifluoroacetate) in high overall yield.