The Journal of Organic Chemistry

Tandem alkylation-reduction of 2-acylpyrroles. Convenient one-pot syntheses of 2-benzylpyrroles

DP Schumacher, SS Hall

Index: Schumacher, Doris P.; Hall, Stan S. Journal of Organic Chemistry, 1981 , vol. 46, p. 5060 - 5064

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Abstract

Tandem alkylation-reduction of 2-acylpyrroles is described for the convenient one-pot syntheses of 2-benzylpyrroles. By this convenient procedure 2-(p-methoxybenzyl) pyrrole (2), 2-benzylpyrrole (3), 2-(pmethylbenzy1) pyrrole (4), 2-(o-methoxybenzyl) pyrrole (5), and 2-(m-methoxybenzyl) pyrrole (6) were prepared from p-methoxyphenyllithium, phenyllithium, p-tolyllithium, o-methoxyphenyllithium, and m-methoxyphenyllithium, respectively. ...