Synthesis and DNA-sequence selectivity of a series of mono-and difunctional 9-aminoacridine nitrogen mustards

KW Kohn, A Orr, PM O'Connor, LJ Guziec…

Index: Kohn, Kurt W.; Orr, Ann; O'Connor, Patrick M.; Guziec, Lynn James; Guziec, Frank S. Journal of Medicinal Chemistry, 1994 , vol. 37, # 1 p. 67 - 72

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Citation Number: 40

Abstract

The aim of this work was to identify nitrogen mustards that would react selectively with DNA, particularly in G-rich regions. A series of mono-and difunctional nitrogen mustards was synthesized in which the (2-chloroethy1) amino functions were connected to the W of 9- aminoacridine by way of a spacer chain consisting of two to six methylene units. The length of the spacer chain connecting the alkylating and putative DNA-intercalating groups was ...