Synthesis and biological activity of a novel adenosine analog 3-. beta.-D-ribofuranosylthieno [2, 3-d] pyrimidin-4-one

…, LL Wotring, LC Bloomer, LB Townsend

Index: Patil, Vemanna D.; Wise, Dean S.; Wotring, Linda L.; Bloomer, Linda C.; Townsend, Leroy B. Journal of Medicinal Chemistry, 1985 , vol. 28, # 4 p. 423 - 427

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Citation Number: 28

Abstract

The title nucleoside 5 was prepared by a condensation of the silylated heterocycle thieno [2, 3-d] pyrimidin-4-one (1) with 1-0-acetyl-2, 3, 5-tri-O-benzoyl-@-~-ribofuranose (2a) in the presence of a Lewis acid or with 2, 3, 5-tri-O-acetyl-D-ribofuranosyl bromide (2b) in the presence of mercuric oxide and mercuric bromide. The site of ribosylation and anomeric configuration of this nucleoside were established by lH NMR. The synthesis of 3-PD-ribo- ...