Chemistry Letters

An Efficient Catalytic Friedel-Crafts Acylation Reaction of Equimolar Amounts of Aromatic Compounds and Free Carboxylic Acids or Their Trimethylsilylesters via …

T Mukaiyama, K Suzuki

Index: Mukaiyama, Teruaki; Suzuki, Kaoru Chemistry Letters, 1992 , # 9 p. 1751 - 1754

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Citation Number: 4

Abstract

In the presence of an active catalyst generated from SiCl 4 and AgClO 4, the Friedel-Crafts acylation reaction between equimolar amounts of aromatic compounds and mixed anhydrides, formed in situ from free carboxylic acids (or their trimethylsilylesters) and p- trifluoromethylbenzoic anhydride, smoothly proceeds at room temperature to afford the corresponding aromatic ketones in high yields.