Anticonvulsant activity and interactions with neuronal voltage-dependent sodium channel of analogues of ameltolide

…, D Lambert, JH Poupaert, B Masereel…

Index: Vamecq, Joseph; Lambert, Didier; Poupaert, Jacques H.; Masereel, Bernard; Stables, James P. Journal of Medicinal Chemistry, 1998 , vol. 41, # 18 p. 3307 - 3313

Full Text: HTML

Citation Number: 51

Abstract

Fifteen compounds related to ameltolide (LY 201116) were studied for (i) anticonvulsant potential in the maximal electroshock-induced seizures (MES) and the subcutaneous pentylenetetrazol (sc Ptz) tests in mice and rats and (ii) interactions with neuronal voltage- dependent sodium channels. Compounds were chosen ranging in anticonvulsant activity in mice from very active to inactive. The active compounds were defined as those protecting ...