Journal of the American Chemical Society

Nickel-catalyzed coupling reactions of alkyl electrophiles, including unactivated tertiary halides, to generate carbon–boron bonds

AS Dudnik, GC Fu

Index: Dudnik, Alexander S.; Fu, Gregory C. Journal of the American Chemical Society, 2012 , vol. 134, # 25 p. 10693 - 10697

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Citation Number: 87

Abstract

Through the use of a catalyst formed in situ from NiBr2· diglyme and a pybox ligand (both of which are commercially available), we have achieved our first examples of coupling reactions of unactivated tertiary alkyl electrophiles, as well as our first success with nickel- catalyzed couplings that generate bonds other than C–C bonds. Specifically, we have determined that this catalyst accomplishes Miyaura-type borylations of unactivated tertiary, ...