Journal of medicinal chemistry

Synthesis and antiinflammatory activity of some 2-aryl-6-benzoxazoleacetic acid derivatives

DW Dunwell, D Evans

Index: Dunwell,D.W.; Evans,D. Journal of Medicinal Chemistry, 1977 , vol. 20, p. 797 - 801

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Citation Number: 52

Abstract

Various approaches to the synthesis of 2-aryl-6-substituted benzoxazoles are described. The products, which included the 6-methyl derivative 4a, ethylamines 10 and 19, ethanols 12 and 14, the acetic and a-methylacetic acids 9 and 16a-f, and the acetic ester 11, were screened for antiinflammatory activity on the carrageenan-induced rat paw edema test. Some of the compounds possessed activity superior to that of phenylbutazone and of the ...

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