Analogs of 3??(1??phenyl??3??oxobutyl)??4??hydroxycoumarin (warfarin) prepared from substituted salicylic acids

AO Obaseki, JE Steffen…

Index: Obaseki, Andrew O.; Steffen, James E.; Porter, William R. Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 529 - 533

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Citation Number: 10

Abstract

Abstract Some derivatives of salicylic acid containing substituents meta to the carboxyl group were used to prepare analogs of the anticoagulant drug warfarin, 3-(1-phenyl-3- oxobutyl)-4-hydroxycoumarin, containing substituents in either the 6-or 8-position of the courmarin ring. When the substituent was the hydroxyl group, the resulting products are previously identified metabolites of warfarin. The substituted salicylic acid is first ...