Conformation of Peptides Containing a Chiral α??Ethylated α, α??Disubstituted α??Amino Acid:(S)?螃窿?Ethylleucine (=(2S)??2??Amino??2??ethyl??4??methylpentanoic Acid) …

…, M Tanaka, M Kurihara, H Suemune

Index: Oba, Makoto; Tanaka, Masakazu; Kurihara, Masaaki; Suemune, Hiroshi Helvetica Chimica Acta, 2002 , vol. 85, # 10 p. 3197 - 3218

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Citation Number: 31

Abstract

Abstract An optically active (S)-α-ethylleucine ((S)-αEtLeu) as a chiral α-ethylated α, α- disubstituted α-amino acid was synthesized by means of a chiral acetal auxiliary of (R, R)- cyclohexane-1, 2-diol. The chiral α-ethylated α, α-disubstituted amino acid (S)-αEtLeu was introduced into the peptides constructed from 2-aminoisobutyric acid (= dimethylglycine, Aib), and also into the peptide prepared from diethylglycine (Deg). The X-ray ...