Design, synthesis, and structure− activity relationships of benzophenone-based tetraamides as novel antibacterial agents

…, CM Cheung, MJ Rybak, SM Firestine

Index: Vooturi, Sunil K.; Cheung, Chrissy M.; Rybak, Michael J.; Firestine, Steven M. Journal of Medicinal Chemistry, 2009 , vol. 52, # 16 p. 5020 - 5031

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Citation Number: 45

Abstract

The increase in the incidence of both hospital-and community-acquired antibiotic-resistant infections is a major concern to the healthcare community. There have been only two new classes of antibiotics approved by the FDA over the past 40 years, and clearly there is a growing need for additional antimicrobial agents. In this paper, we present our work on the discovery of a class of benzophenone containing compounds that possess good activity ...