Tetrahedron

Reactions of phosphine with ketones: A route to primary phosphine oxides

SA Buckler, M Epstein

Index: Buckler,S.A.; Epstein,M. Tetrahedron, 1962 , vol. 18, p. 1211 - 1219

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Citation Number: 24

Abstract

Earlier work on the reaction of phosphine with carbonyl compounds is reviewed and new information is provided on the reaction of phosphines with ketones. Primary phosphine oxides (X) and 1-hydroxy secondary phosphine oxides (XI) are formed in strongly acidic media and the ratio of the two products is determined by steric factors; the former predominate with more hindered ketones. The primary phosphine oxides are a novel ...