High-resolution nuclear magnetic resonance investigations of the chemical stability of cyclophosphamide and related phosphoramidic compounds

G Zon, SM Ludeman, W Egan

Index: Zon,G. et al. Journal of the American Chemical Society, 1977 , vol. 99, p. 5785 - 5795

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Citation Number: 37

Abstract

Abstract: High-resolution 1H (220 MHz) and I3C (68 MHz) nuclear magnetic resonance (NMR) spectroscopy was used to investigate the chemical stability of the anticancer drug cyclophosphamide [2-[bis (2-chloroethyl) amino]-2H-I, 3, 2-oxazaphosphorinane 2-oxide, 11, N-methylcyclophosphamide (6), isophosphamide [2-(2-~ hloroethylamino)-3-(2-~ hloroethyl)-2H-