Synthesis of cyclohexylaliphatic acids and their pharmacological properties

…, B Brunová, J Grimová, S Vaněček…

Index: Kuchar, Miroslav; Brunova, Bohumila; Grimova, Jaroslava; Vanecek, Stanislav; Holubek, Jiri Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 12 p. 2896 - 2908

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Abstract

Abstract A series of substituted cyclohexylacetic acids I has been obtained by hydrogenation of the unsaturated analogues II and III. Esters of these analogues were prepared by the Horner-Wittig reaction of the corresponding cyclohexanones IV and/or 2-cyclohexenones V with triethyl phosphonoacetate. These esters were obtained in two isomeric forms (Z and E), differing in the double bond in the exo-position. The derivatives with a substituent in the 2- ...