Anti-malarial activities of acylated bruceolide derivatives

…, M Sugimoto, M Kobayashi, Y Wataya, HS Kim

Index: Murakarni, Nobutoshi; Umezome, Takashi; Mahmud, Taifo; Sugimoto, Masanori; Kobayashi, Motomasa; Wataya, Yusuke; Kim, Hye-Sook Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 5 p. 459 - 462

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Citation Number: 13

Abstract

Several O-acylated derivatives of bruceolide (2) were synthesized and their anti-malarial activities together with selective toxicities were examined. It was found that 3, 15-di-O-acetyl- (3c), 3, 15-di-O-propionyl-(3d) and 15-O-propionylbruceolide (3b), as well as bruceine B (3a), exhibited potent anti-malarial activities with high selective toxicities.