Tetrahedron

Total synthesis of zyzzyanones A–D

DH Nadkarni, S Murugesan, SE Velu

Index: Nadkarni, Dwayaja H.; Murugesan, Srinivasan; Velu, Sadanandan E. Tetrahedron, 2013 , vol. 69, # 20 p. 4105 - 4113

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Citation Number: 10

Abstract

Zyzzyanones A–D is a group of biologically active marine alkaloids isolated from Australian marine sponge Zyzzya fuliginosa. They contain a unique bispyrroloquinone ring system as the core structure. The first total synthesis of all four zyzzyanones is described here. The synthesis of these alkaloids started from a previously known 6-benzylamino indole-4, 7- quinone derivative and involves 6–7 steps. The key step in the synthesis involves the ...