Folate antagonists. 5. Antimalarial and antibacterial effects of 2, 4??diamino??6??(aryloxy and aralkoxy) quinazoline antimetabolites

EF Elslager, J Clarke, J Johnson…

Index: Elslager,E.F. et al. Journal of Heterocyclic Chemistry, 1972 , vol. 9, p. 759 - 773

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Citation Number: 15

Abstract

Abstract 2 Various4-diamino-6-(phenoxy, naphthyloxy, and phenalkoxy) quinazolines (VIII, XIV) were synthesized for antimalarial and antibacterial evaluation. Treatment of the anion of the requisite phenol or naphthol with 5-chloro-2-nitrobenzonitrile (V) gave the corresponding 2-nitro-5-(phenoxy and naphthyloxy) benzonitriles (VI)(33–78%). Alternatively, alkylation of 5-hydroxy-2-nitrobenzaldehyde (IX) with the appropriate phenalkyl halide afforded the 2- ...