Tetrahedron letters

A concise synthesis of a new xylyl-biaryl diphosphine ligand for asymmetric hydrogenation of ketones

JP Henschke, A Zanotti-Gerosa, P Moran, P Harrison…

Index: Henschke, Julian P.; Zanotti-Gerosa, Antonio; Moran, Paul; Harrison, Paul; Mullen, Brendan; Casy, Guy; Lennon, Ian C. Tetrahedron Letters, 2003 , vol. 44, # 23 p. 4379 - 4383

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Citation Number: 48

Abstract

A concise synthesis of a symmetrical biaryl diphosphine ligand bearing 3, 5-dimethylphenyl substituents at phosphorus is described. The ruthenium catalysts [diphosphine RuCl2 diamine] containing the new ligand Xyl-TetraPHEMP were found to be as active and as selective as the state-of-the-art catalysts for homogeneous asymmetric ketone hydrogenation.