Nickel-catalyzed Suzuki–Miyaura reaction of aryl fluorides

…, T Xu, T Shimasaki, N Chatani

Index: Shiota, Hirotaka; Ano, Yusuke; Aihara, Yoshinori; Fukumoto, Yoshiya; Chatani, Naoto Journal of the American Chemical Society, 2011 , vol. 133, # 38 p. 14952 - 14955

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Citation Number: 101

Abstract

Two protocols for the nickel-catalyzed cross-coupling of aryl fluorides with aryl boronic esters have been developed. The first employs metal fluoride cocatalysts, such as ZrF4 and TiF4, which enable Suzuki–Miyaura reactions of aryl fluorides bearing electron-withdrawing (ketones, esters, and CF3), aryl and alkenyl groups as well as those comprising fused aromatic rings, such as fluoronaphthalenes and fluoroquinolines. The second protocol ...