Zinc-Mediated Allylation and Alkylation of Aminals in the Presence of TMSCl and Diisopropylamine

B Hatano, K Nagahashi, T Kijima

Index: Hatano, Bunpei; Nagahashi, Keita; Kijima, Tatsuro Journal of Organic Chemistry, 2008 , vol. 73, # 22 p. 9188 - 9191

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Citation Number: 16

Abstract

Nucleophilic additions to carbonyl compounds and imines with organometallic reagents are important for syntheses of functionalized alcohols and amines. Among them, addition using organozinc reagents based on Barbier-and Reformatsky-type reactions is a useful method in organic synthesis because the organozinc reagents are readily prepared in situ from the corresponding alkyl bromide, such as allyl bromide and R-bromoacetate, in the presence ...