The Journal of Organic Chemistry

A New Method for Expeditious Ketone Synthesis from Acids via Acyl Hemiacetals

MN Mattson, H Rapoport

Index: Mattson, Matthew N.; Rapoport, Henry Journal of Organic Chemistry, 1996 , vol. 61, # 17 p. 6071 - 6074

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Citation Number: 30

Abstract

Since ketones are common and versatile functionalities in organic synthesis for both carbon- carbon bond formation and functional group interconversion, a large number of methods for their convergent construction has been developed. The synthesis of ketones from organometallic reagents and carboxylic acids and their derivatives has been explored exhaustively for a large variety of combinations. 1 However, acylation methods that are ...