Tetrahedron Letters

Dry reaction of indoles with carbonyl compounds on montmorillonite K10 clay: a mild, expedient synthesis of diindolylalkanes and vibrindole A

M Chakrabarty, N Ghosh, R Basak, Y Harigaya

Index: Chakrabarty, Manas; Ghosh, Nandita; Basak, Ramkrishna; Harigaya, Yoshihiro Tetrahedron Letters, 2002 , vol. 43, # 22 p. 4075 - 4078

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Citation Number: 172

Abstract

Dry reaction of indoles 1a–c with aldehydes 2a–i, ketones 2j–o and an acetal 2p on M. K10 clay at room temperature furnished 3, 3′-diindolylalkanes (DIAs: 3a–h, j–r). The novel formation of tris (3-indolyl) methane 4 from 2i through tandem reactions and of the DIAs 6 and 8 from 1d through Plancher rearrangements were also observed.