Thermostable enzymes in organic synthesis. 7. Total synthesis of the western corn rootworm sex pheromone 8-methyldec-2-yl propanoate using a TBADH-generated …

…, SC Sinha, A Sinha-Bagchi

Index: Keinan, Ehud; Sinha, Subhash C.; Sinha-Bagchi, Anjana Journal of Organic Chemistry, 1992 , vol. 57, # 13 p. 3631 - 3636

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Citation Number: 38

Abstract

Enantiomerically pure alcohols produced by Thermoanaerobium brockii alcohol dehydrogenase (TBADH)-catalyd asymmetric reduction of polyfunctional ketones are useful building blocks for natural products synthesis. This advantage has been demonstrated by a total synthesis of all four isomers of 8-methyldec-2-yl propanoate, the sex pheromone emitted by the female weatem com rootworm, Diubrotica virgifera virgifera Leconte. These ...