Identification of a Novel Cardenolide (2''-Oxovoruscharin) from Calotropis p rocera and the Hemisynthesis of Novel Derivatives Displaying Potent in Vitro Antitumor …

…, C Decaestecker, JC Braekman, R Kiss…

Index: Joseph, Benoit; Darro, Francis; Behard, Aurelie; Lesur, Brigitte; Collignon, Francoise; Decaestecker, Christine; Frydman, Armand; Guillaumet, Gerald; Kiss, Robert Journal of Medicinal Chemistry, 2002 , vol. 45, # 12 p. 2543 - 2555

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Citation Number: 149

Abstract

Analysis of the methanolic extract of Calotropis procera root barks enabled the identification of a novel cardenolide (2''-oxovoruscharin) to be made. Of the 27 compounds that we hemisynthesized, one (23) exhibited a very interesting profile with respect to its hemisynthetic chemical yield, its in vitro antitumor activity, its in vitro inhibitory influence on the Na+/K+-ATPase activity, and its in vivo tolerance. Compound 23 displayed in vitro ...