A General Strategy for the Perfluoroalkylation of Arenes and Arylbromides by Using Arylboronate Esters and [(phen) CuRF]

ND Litvinas, PS Fier, JF Hartwig

Index: Litvinas, Nichole D.; Fier, Patrick S.; Hartwig, John F. Angewandte Chemie - International Edition, 2012 , vol. 51, # 2 p. 536 - 539

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Citation Number: 158

Abstract

A large number of existing and candidate pharmaceuticals contain perfluoroalkyl groups because these moieties can favorably affect the physical and biological properties of a compound.[1] Accordingly, the development of methods to introduce perfluoroalkyl groups into aromatic compounds has become increasingly important. To introduce the CF3 moiety, the simplest perfluoroalkyl group, most current industrial methods rely on the Swarts ...