Some synthetic approaches to ropinirole (sk&f 101468??a): A potent dopamine receptor agonist

JD Hayler, SLB Howie, RG Giles…

Index: Journal of Heterocyclic Chemistry, , vol. 32, # 3 p. 875 - 882

Full Text: HTML

Citation Number: 18

Abstract

... 875 J. Heterocyclic Chem., 32, 875 (1995). ... Since a reason- able level of success had been achieved in preparing the bromide precursor 11 using the ferric chloride cyclisation chemistry, it was decided to try this approach to prepare alcohol 16. ...

 Related Synthetic Route
Isochroman Structure

493-05-0

Isochroman

~%

Ropinirole Structure

91374-21-9

Ropinirole

3,4-dihydro-1H-isochromen-1-ol Structure

95033-78-6

3,4-dihydro-1H-...

~%

Ropinirole Structure

91374-21-9

Ropinirole

1,3-Dihydro-4-(2-hydroxyethyl)-2H-indole-2-one Structure

139122-19-3

1,3-Dihydro-4-(...

~%

Ropinirole Structure

91374-21-9

Ropinirole

4-(2'-BROMOETHYL)-1,3-DIHYDRO-2H-INDOLE-2-ONE Structure

120427-96-5

4-(2'-BROMOETHY...

~%

Ropinirole Structure

91374-21-9

Ropinirole

4-(2-acetoxyethyl)-1,3-dihydro-2H-indolin-2-one Structure

168476-61-7

4-(2-acetoxyeth...

~%

Ropinirole Structure

91374-21-9

Ropinirole

Benzeneethanol, 2-(chloromethyl)-, 1-benzoate Structure

168476-58-2

Benzeneethanol,...

~%

Ropinirole Structure

91374-21-9

Ropinirole

Benzaldehyde, 2-[2-(benzoyloxy)ethyl]- Structure

139122-15-9

Benzaldehyde, 2...

~%

Ropinirole Structure

91374-21-9

Ropinirole

N/A Structure

168476-57-1

N/A

~%

Ropinirole Structure

91374-21-9

Ropinirole

2-(2-oxo-1,3-dihydroindol-4-yl)ethyl benzoate Structure

139122-18-2

2-(2-oxo-1,3-di...

~%

Ropinirole Structure

91374-21-9

Ropinirole

2-(3-chloro-2-oxo-1,3-dihydroindol-4-yl)ethyl benzoate Structure

139122-17-1

2-(3-chloro-2-o...

~%

Ropinirole Structure

91374-21-9

Ropinirole

Tosyl chloride Structure

98-59-9

Tosyl chloride

1,3-Dihydro-4-(2-hydroxyethyl)-2H-indole-2-one Structure

139122-19-3

1,3-Dihydro-4-(...

~88%

4-[2'-[[(4-Methylphenyl)sulfonyl]oxy]ethyl]-1,3-dihydro-2H-indole-2-one Structure

139122-20-6

4-[2'-[[(4-Meth...

2-(2-Bromoethyl)benzaldehyde Structure

22901-09-3

2-(2-Bromoethyl...

~%

4-[2'-[[(4-Methylphenyl)sulfonyl]oxy]ethyl]-1,3-dihydro-2H-indole-2-one Structure

139122-20-6

4-[2'-[[(4-Meth...

4-(2'-BROMOETHYL)-3-CHLORO-1,3-DIHYDRO-2H-INDOLE-2-ONE Structure

120427-95-4

4-(2'-BROMOETHY...

~%

4-[2'-[[(4-Methylphenyl)sulfonyl]oxy]ethyl]-1,3-dihydro-2H-indole-2-one Structure

139122-20-6

4-[2'-[[(4-Meth...

2-(2-oxo-1,3-dihydroindol-4-yl)ethyl benzoate Structure

139122-18-2

2-(2-oxo-1,3-di...

~%

4-[2'-[[(4-Methylphenyl)sulfonyl]oxy]ethyl]-1,3-dihydro-2H-indole-2-one Structure

139122-20-6

4-[2'-[[(4-Meth...

2-(3-chloro-2-oxo-1,3-dihydroindol-4-yl)ethyl benzoate Structure

139122-17-1

2-(3-chloro-2-o...

~%

4-[2'-[[(4-Methylphenyl)sulfonyl]oxy]ethyl]-1,3-dihydro-2H-indole-2-one Structure

139122-20-6

4-[2'-[[(4-Meth...

Isochroman Structure

493-05-0

Isochroman

~%

4-[2'-[[(4-Methylphenyl)sulfonyl]oxy]ethyl]-1,3-dihydro-2H-indole-2-one Structure

139122-20-6

4-[2'-[[(4-Meth...

3,4-dihydro-1H-isochromen-1-ol Structure

95033-78-6

3,4-dihydro-1H-...

~%

4-[2'-[[(4-Methylphenyl)sulfonyl]oxy]ethyl]-1,3-dihydro-2H-indole-2-one Structure

139122-20-6

4-[2'-[[(4-Meth...

4-(2'-BROMOETHYL)-1,3-DIHYDRO-2H-INDOLE-2-ONE Structure

120427-96-5

4-(2'-BROMOETHY...

~%

4-[2'-[[(4-Methylphenyl)sulfonyl]oxy]ethyl]-1,3-dihydro-2H-indole-2-one Structure

139122-20-6

4-[2'-[[(4-Meth...

4-(2-acetoxyethyl)-1,3-dihydro-2H-indolin-2-one Structure

168476-61-7

4-(2-acetoxyeth...

~%

4-[2'-[[(4-Methylphenyl)sulfonyl]oxy]ethyl]-1,3-dihydro-2H-indole-2-one Structure

139122-20-6

4-[2'-[[(4-Meth...

Benzeneethanol, 2-(chloromethyl)-, 1-benzoate Structure

168476-58-2

Benzeneethanol,...

~%

4-[2'-[[(4-Methylphenyl)sulfonyl]oxy]ethyl]-1,3-dihydro-2H-indole-2-one Structure

139122-20-6

4-[2'-[[(4-Meth...

Benzaldehyde, 2-[2-(benzoyloxy)ethyl]- Structure

139122-15-9

Benzaldehyde, 2...

~%

4-[2'-[[(4-Methylphenyl)sulfonyl]oxy]ethyl]-1,3-dihydro-2H-indole-2-one Structure

139122-20-6

4-[2'-[[(4-Meth...

N/A Structure

168476-57-1

N/A

~%

4-[2'-[[(4-Methylphenyl)sulfonyl]oxy]ethyl]-1,3-dihydro-2H-indole-2-one Structure

139122-20-6

4-[2'-[[(4-Meth...

Isochroman Structure

493-05-0

Isochroman

~%

2-(3-chloro-2-oxo-1,3-dihydroindol-4-yl)ethyl benzoate Structure

139122-17-1

2-(3-chloro-2-o...

Benzoyl chloride Structure

98-88-4

Benzoyl chloride

~%

2-(3-chloro-2-oxo-1,3-dihydroindol-4-yl)ethyl benzoate Structure

139122-17-1

2-(3-chloro-2-o...

Benzeneethanol, 2-(chloromethyl)-, 1-benzoate Structure

168476-58-2

Benzeneethanol,...

~%

2-(3-chloro-2-oxo-1,3-dihydroindol-4-yl)ethyl benzoate Structure

139122-17-1

2-(3-chloro-2-o...

Benzaldehyde, 2-[2-(benzoyloxy)ethyl]- Structure

139122-15-9

Benzaldehyde, 2...

~%

2-(3-chloro-2-oxo-1,3-dihydroindol-4-yl)ethyl benzoate Structure

139122-17-1

2-(3-chloro-2-o...

2-(2-Bromoethyl)benzaldehyde Structure

22901-09-3

2-(2-Bromoethyl...

~%

1,3-Dihydro-4-(2-hydroxyethyl)-2H-indole-2-one Structure

139122-19-3

1,3-Dihydro-4-(...

4-(2'-BROMOETHYL)-3-CHLORO-1,3-DIHYDRO-2H-INDOLE-2-ONE Structure

120427-95-4

4-(2'-BROMOETHY...

~%

1,3-Dihydro-4-(2-hydroxyethyl)-2H-indole-2-one Structure

139122-19-3

1,3-Dihydro-4-(...

4-(2-acetoxyethyl)-1,3-dihydro-2H-indolin-2-one Structure

168476-61-7

4-(2-acetoxyeth...

~68%

1,3-Dihydro-4-(2-hydroxyethyl)-2H-indole-2-one Structure

139122-19-3

1,3-Dihydro-4-(...

2-(2-oxo-1,3-dihydroindol-4-yl)ethyl benzoate Structure

139122-18-2

2-(2-oxo-1,3-di...

~%

1,3-Dihydro-4-(2-hydroxyethyl)-2H-indole-2-one Structure

139122-19-3

1,3-Dihydro-4-(...

Isochroman Structure

493-05-0

Isochroman

~%

1,3-Dihydro-4-(2-hydroxyethyl)-2H-indole-2-one Structure

139122-19-3

1,3-Dihydro-4-(...

3,4-dihydro-1H-isochromen-1-ol Structure

95033-78-6

3,4-dihydro-1H-...

~%

1,3-Dihydro-4-(2-hydroxyethyl)-2H-indole-2-one Structure

139122-19-3

1,3-Dihydro-4-(...

4-(2'-BROMOETHYL)-1,3-DIHYDRO-2H-INDOLE-2-ONE Structure

120427-96-5

4-(2'-BROMOETHY...

~%

1,3-Dihydro-4-(2-hydroxyethyl)-2H-indole-2-one Structure

139122-19-3

1,3-Dihydro-4-(...

Benzeneethanol, 2-(chloromethyl)-, 1-benzoate Structure

168476-58-2

Benzeneethanol,...

~%

1,3-Dihydro-4-(2-hydroxyethyl)-2H-indole-2-one Structure

139122-19-3

1,3-Dihydro-4-(...

Benzaldehyde, 2-[2-(benzoyloxy)ethyl]- Structure

139122-15-9

Benzaldehyde, 2...

~%

1,3-Dihydro-4-(2-hydroxyethyl)-2H-indole-2-one Structure

139122-19-3

1,3-Dihydro-4-(...

N/A Structure

168476-57-1

N/A

~%

1,3-Dihydro-4-(2-hydroxyethyl)-2H-indole-2-one Structure

139122-19-3

1,3-Dihydro-4-(...

2-(2-Bromoethyl)benzaldehyde Structure

22901-09-3

2-(2-Bromoethyl...

~%

4-(2'-BROMOETHYL)-3-CHLORO-1,3-DIHYDRO-2H-INDOLE-2-ONE Structure

120427-95-4

4-(2'-BROMOETHY...

2-(2-Bromoethyl)benzaldehyde Structure

22901-09-3

2-(2-Bromoethyl...

~%

4-(2'-BROMOETHYL)-1,3-DIHYDRO-2H-INDOLE-2-ONE Structure

120427-96-5

4-(2'-BROMOETHY...

2-(2-Bromoethyl)benzaldehyde Structure

22901-09-3

2-(2-Bromoethyl...

~%

Ropinirole Structure

91374-21-9

Ropinirole

4-(2'-BROMOETHYL)-3-CHLORO-1,3-DIHYDRO-2H-INDOLE-2-ONE Structure

120427-95-4

4-(2'-BROMOETHY...

~%

Ropinirole Structure

91374-21-9

Ropinirole


Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved